The immunology of fibrosis: innate and adaptive responses
نویسندگان
چکیده
منابع مشابه
The immunology of fibrosis: innate and adaptive responses.
Fibrosis is an important health problem, and its pathogenetic principles are still largely unknown. It can develop either spontaneously, or, more frequently, as a consequence of various underlying diseases. Irrespective of the primary cause, however, fibrotic tissue is always infiltrated by mononuclear immune cells. In most instances the reason for the attraction of these cells to fibrotic tiss...
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Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. Furthermore, they secrete interferon-γ (IFN-γ) and tumor necrosis factor (TNF) prompting adaptive immu-nity. NK cells distinguish the unhealthy cells from the healthy ones through an array of cell-surface receptors. Human NK cells use inhibi...
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ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2010
ISSN: 1471-4906
DOI: 10.1016/j.it.2009.12.001